Tyler C. McFayden, Clare Harrop, Kyle Roell, Robert M. Joseph, Rebecca C. Fry & T. Michael O\u2019Shea<\/p>\n
Purpose<\/p>\n
To evaluate sex differences in autistic traits in youth born extremely preterm (EP; 23\u201327 weeks) who were later diagnosed with autism spectrum disorder (ASD) at 10-years.<\/p>\n
\u00a0<\/p>\n
Method<\/p>\n
A longitudinal cohort design from the Extremely Low Gestational Age Newborn Study (ELGAN) followed N\u2009=\u2009857 EP infants from birth through 10-years. EP infants later diagnosed with ASD (N\u2009=\u200961, 20 females) participated in the study. Group differences were evaluated via inferential and Bayesian statistics (values\u2009>\u20091 suggest evidence for alternate hypothesis) on ASD screeners (M-CHAT at 2-years, SCQ and SRS-2 at 10-years), and gold-standard diagnostic measures (ADOS-2, ADI-R) at 10-years.<\/p>\n
\u00a0<\/p>\n
Results<\/p>\n
Males scored significantly higher than females on measures of Social Affect from the ADOS-2, t(34.27)=-2.20, BF10\u2009=\u20092.33, and measures of Repetitive and Restricted Behaviors from the ADI-R, t(40.52)=-2.85, BF10\u2009=\u20095.26. Bayesian estimates suggested marginal evidence for sex differences in Nonverbal Communication, t(30.66)=-1.81, BF10\u2009=\u20091.25, and Verbal Communication, t(24.64)=-1.89, BF10\u2009=\u20091.39, from the ADI-R, wherein males scored higher than females. No statistically significant sex differences were identified on any of the ASD screeners at 2 (M-CHAT) or 10 years (SCQ). No significant sex differences were observed on any subscales of the SRS at 10 years.<\/p>\n
\u76ee\u7684<\/p>\n
\u8bc4\u4f30\u6781\u65e9\u4ea7\u513f\uff08EP\uff1b23-27 \u5468\uff09\u9752\u5c11\u5e74\u81ea\u95ed\u75c7\u7279\u5f81\u7684\u6027\u522b\u5dee\u5f02\uff0c\u8fd9\u4e9b\u9752\u5c11\u5e74\u5728 10 \u5c81\u65f6\u88ab\u8bca\u65ad\u51fa\u60a3\u6709\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u3002<\/p>\n
\u00a0<\/p>\n
\u7814\u7a76\u65b9\u6cd5<\/p>\n
\u91c7\u7528\u6781\u4f4e\u598a\u5a20\u5e74\u9f84\u65b0\u751f\u513f\u7814\u7a76\uff08ELGAN\uff09\u7684\u7eb5\u5411\u961f\u5217\u8bbe\u8ba1\uff0c\u5bf9 N = 857 \u540d\u6781\u5ea6\u65e9\u4ea7\u513f\u8fdb\u884c\u4e86\u4ece\u51fa\u751f\u5230 10 \u5e74\u7684\u8ddf\u8e2a\u7814\u7a76\u3002\u540e\u6765\u88ab\u8bca\u65ad\u4e3a ASD \u7684 EP \u5a74\u513f\uff08N = 61\uff0c20 \u540d\u5973\u6027\uff09\u53c2\u4e0e\u4e86\u7814\u7a76\u3002\u901a\u8fc7\u63a8\u8bba\u548c\u8d1d\u53f6\u65af\u7edf\u8ba1\uff08\u503c > 1 \u8868\u660e\u6709\u8bc1\u636e\u652f\u6301\u53e6\u4e00\u5047\u8bbe\uff09\u5bf9 ASD \u7b5b\u67e5\u6307\u6807\uff082 \u5c81\u65f6\u7684 M-CHAT\u300110 \u5c81\u65f6\u7684 SCQ \u548c SRS-2\uff09\u548c 10 \u5c81\u65f6\u7684\u9ec4\u91d1\u6807\u51c6\u8bca\u65ad\u6307\u6807\uff08ADOS-2\u3001ADI-R\uff09\u8fdb\u884c\u4e86\u7fa4\u4f53\u5dee\u5f02\u8bc4\u4f30\u3002<\/p>\n
\u00a0<\/p>\n
\u7ed3\u679c<\/p>\n
\u5728ADOS-2\u7684\u793e\u4ea4\u60c5\u611f\u6d4b\u91cf\u4e2d\uff0c\u7537\u6027\u5f97\u5206\u660e\u663e\u9ad8\u4e8e\u5973\u6027\uff0ct(34.27)=-2.20, BF10 = 2.33\uff1b\u5728ADI-R\u7684\u91cd\u590d\u548c\u53d7\u9650\u884c\u4e3a\u6d4b\u91cf\u4e2d\uff0c\u7537\u6027\u5f97\u5206\u660e\u663e\u9ad8\u4e8e\u5973\u6027\uff0ct(40.52)=-2.85, BF10 = 5.26\u3002\u8d1d\u53f6\u65af\u4f30\u8ba1\u7ed3\u679c\u8868\u660e\uff0cADI-R \u7684\u975e\u8bed\u8a00\u6c9f\u901a\uff08t(30.66)=-1.81, BF10 = 1.25\uff09\u548c\u8bed\u8a00\u6c9f\u901a\uff08t(24.64)=-1.89, BF10 = 1.39\uff09\u65b9\u9762\u5b58\u5728\u8fb9\u7f18\u6027\u6027\u522b\u5dee\u5f02\uff0c\u5176\u4e2d\u7537\u6027\u5f97\u5206\u9ad8\u4e8e\u5973\u6027\u3002\u5728 2 \u5e74\uff08M-CHAT\uff09\u6216 10 \u5e74\uff08SCQ\uff09\u7684\u4efb\u4f55 ASD \u7b5b\u67e5\u6307\u6807\u4e0a\uff0c\u5747\u672a\u53d1\u73b0\u660e\u663e\u7684\u6027\u522b\u5dee\u5f02\u300210 \u5e74\u540e\uff0cSRS \u7684\u4efb\u4f55\u5206\u91cf\u8868\u5747\u672a\u53d1\u73b0\u660e\u663e\u7684\u6027\u522b\u5dee\u5f02\u3002<\/p>\n\n\n
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Tyler C. McFayden, Clare Harrop, Kyle Roell, Robert M. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[30,29,31],"class_list":["post-3535","post","type-post","status-publish","format-standard","hentry","category-research_paper","tag-children","tag-iep","tag-paper"],"_links":{"self":[{"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/posts\/3535"}],"collection":[{"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3535"}],"version-history":[{"count":1,"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/posts\/3535\/revisions"}],"predecessor-version":[{"id":3536,"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/posts\/3535\/revisions\/3536"}],"wp:attachment":[{"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nsercca.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}